Proangiogenic function of CD40 ligand-CD40 interactions.

  title={Proangiogenic function of CD40 ligand-CD40 interactions.},
  author={Marlies E. J. Reinders and Masayuki Sho and Stuart W. Robertson and Christopher S. Geehan and David Michael Briscoe},
  journal={Journal of immunology},
  volume={171 3},
Angiogenesis is a characteristic component of cell-mediated immune inflammation. However, little is known of the immunologic mediators of angiogenesis factor production. Interactions between CD40 ligand (CD40L) and CD40 have been shown to have pluripotent functions in inflammation, including the production of cytokines, chemokines, as well as the angiogenesis factor, vascular endothelial growth factor (VEGF), by endothelial cells. In this study we found that treatment of cultured human… CONTINUE READING