Proangiogenic activity in bronchoalveolar lavage fluid from patients with asthma.

  title={Proangiogenic activity in bronchoalveolar lavage fluid from patients with asthma.},
  author={David E Simcock and Varsha Kanabar and Graham W. Clarke and Brian J O'connor and Tak Hong Lee and Stuart J. Hirst},
  journal={American journal of respiratory and critical care medicine},
  volume={176 2},
RATIONALE Asthmatic airways have an increased number and size of vascular structures, which contribute to airflow obstruction and hyperresponsiveness. OBJECTIVES We examined whether proangiogenic mediators are elevated in bronchoalveolar lavage fluid (BALF) from subjects with asthma and if this translated to induction of angiogenesis. METHODS Angiogenic activity in BALF from 12 healthy, nonatopic subjects and 10 atopic subjects with mild asthma was evaluated by examining tubule formation at… CONTINUE READING
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