Proadrenomedullin NH2-terminal 20 peptide has direct vasodilator activity in the cat.

@article{Champion1997ProadrenomedullinN2,
  title={Proadrenomedullin NH2-terminal 20 peptide has direct vasodilator activity in the cat.},
  author={Hunter C. Champion and William J. Murphy and D. H. Coy. E. J. Coy and Philip J. Kadowitz},
  journal={The American journal of physiology},
  year={1997},
  volume={272 4 Pt 2},
  pages={R1047-54}
}
The mechanism by which proadrenomedullin NH2-terminal 20 peptide (PAMP) decreases vascular resistance was investigated in the hindlimb vascular bed in the cat. Injections of PAMP, a shortened form of the peptide PAMP-(12-20), and adrenomedullin (ADM) into the hindlimb perfusion circuit elicit dose-related decreases in perfusion pressure. The order of potency was ADM > PAMP > PAMP-(12-20), and the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP-(8-37) had no effect on vasodilator… CONTINUE READING