ProQ is an RNA chaperone that controls ProP levels in Escherichia coli.

  title={ProQ is an RNA chaperone that controls ProP levels in Escherichia coli.},
  author={Steven G. Chaulk and Michelle N Smith Frieday and David C. Arthur and Doreen E. Culham and Ross A. Edwards and Patrick Lim Soo and Laura S. Frost and Robert A B Keates and J N Mark Glover and Janet M Wood},
  volume={50 15},
Transporter ProP mediates osmolyte accumulation in Escherichia coli cells exposed to high osmolality media. The cytoplasmic ProQ protein amplifies ProP activity by an unknown mechanism. The N- and C-terminal domains of ProQ are predicted to be structurally similar to known RNA chaperone proteins FinO and Hfq from E. coli. Here we demonstrate that ProQ is an RNA chaperone, binding RNA and facilitating both RNA strand exchange and RNA duplexing. Experiments performed with the isolated ProQ… CONTINUE READING


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