Pro42 and Val45 of staphylokinase modulate intermolecular interactions of His43-Tyr44 pair and specificity of staphylokinase-plasmin activator complex.

Abstract

Staphylokinase (SAK) forms a 1:1 stoichiometric complex with plasmin (Pm) and changes its substrate specificity to create a plasminogen (Pg) activator complex. The His(43)-Tyr(44) pair of SAK resides within the active site cleft of the partner Pm and generates intermolecular contacts to confer Pg activator ability to the SAK-Pm bimolecular complex. Site… (More)
DOI: 10.1016/j.febslet.2012.01.046

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Cite this paper

@article{Singh2012Pro42AV, title={Pro42 and Val45 of staphylokinase modulate intermolecular interactions of His43-Tyr44 pair and specificity of staphylokinase-plasmin activator complex.}, author={Satish Singh and Ashish and Kanak L. Dikshit}, journal={FEBS letters}, year={2012}, volume={586 6}, pages={653-8} }