Pro12Ala polymorphism of the peroxisome proliferatoractivated receptor-gamma gene is associated with metabolic syndrome and surrogate measures of insulin resistance in healthy men: interaction with smoking status.

@article{Tellechea2009Pro12AlaPO,
  title={Pro12Ala polymorphism of the peroxisome proliferatoractivated receptor-gamma gene is associated with metabolic syndrome and surrogate measures of insulin resistance in healthy men: interaction with smoking status.},
  author={Mariana Lorena Tellechea and Florencia Aranguren and Mar{\'i}a Silvia P{\'e}rez and Gloria Edith Cerrone and Gustavo Daniel Frechtel and Mariano J Taverna},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  year={2009},
  volume={73 11},
  pages={2118-24}
}
BACKGROUND The Pro12Ala polymorphism (rs1801282), a nonsynonymous substitution of peroxisome proliferator-activated receptor-gamma (PPARG), has been robustly associated with type 2 diabetes. However, its role in metabolic syndrome (MetS) remains poorly understood. The associations among rs1801282, MetS and surrogate measures of insulin resistance (IR) were investigated in the present study. METHODS AND RESULTS A cross-sectional population-based survey of 572 unrelated healthy male Argentinian… CONTINUE READING

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