Pro12Ala polymorphism of the PPAR-γ2 gene, metabolic syndrome and response to metformin in clozapine-treated patients.

@article{Fernandez2012Pro12AlaPO,
  title={Pro12Ala polymorphism of the PPAR-γ2 gene, metabolic syndrome and response to metformin in clozapine-treated patients.},
  author={Erika Patricia Garces Fernandez and Edgardo Carrizo and Lisette Connell and Trino Baptista},
  journal={Schizophrenia research},
  year={2012},
  volume={137 1-3},
  pages={262-3}
}
The peroxisome proliferator-activated receptor gamma (PPAR-γ, PPARG or glitazone receptor) encoded by the PPAR-γ gene is implicated in obesity, diabetes, atherosclerosis and cancer (Costa et al., 2010). The Pro12Ala polymorphism of the PPAR-γ2 gene determines three genotypes. The Ala substitution is associated with a favorable metabolic profile in non-psychiatric populations (Fernández et al., 2009; Costa et al., 2010); however, results are conflicting (Tönjes 

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