Pro-senescent effect of hydrogen peroxide on cancer cells and its possible application to tumor suppression.

Abstract

Mild oxidative stress is known to induce premature senescence, termed stress-induced premature senescence (SIPS), in normal human diploid cells. We investigated to determine whether mild oxidative stress would trigger SIPS in a human tumor cell line, human lung adenocarcinoma A549. The results showed that sublethal concentrations of H(2)O(2) induced SIPS in… (More)

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@article{Yoshizaki2009ProsenescentEO, title={Pro-senescent effect of hydrogen peroxide on cancer cells and its possible application to tumor suppression.}, author={Kaichi Yoshizaki and Tsukasa Fujiki and Takahiro Tsunematsu and Makiko Yamashita and Miyako Udono and Sanetaka Shirahata and Yoshinori Katakura}, journal={Bioscience, biotechnology, and biochemistry}, year={2009}, volume={73 2}, pages={311-5} }