Pro-rich antimicrobial peptides from animals: structure, biological functions and mechanism of action.

@article{Gennaro2002ProrichAP,
  title={Pro-rich antimicrobial peptides from animals: structure, biological functions and mechanism of action.},
  author={Renato Gennaro and Margherita Zanetti and Monica Benincasa and Elena Podda and Monica Miani},
  journal={Current pharmaceutical design},
  year={2002},
  volume={8 9},
  pages={
          763-78
        }
}
Pro-rich antimicrobial peptides are a group of linear peptides of innate immunity isolated from mammals and invertebrates, and characterised by a high content of proline residues (up to 50%). Members of this group are predominantly active against Gram-negative bacterial species which they kill by a non-lytic mechanism, at variance with the majority of the known antimicrobial peptides. Evidence is accumulating that the Pro-rich peptides enter the cells without membrane lysis and, once in the… CONTINUE READING