Pro-protein convertases (PCs) other than PC6 are not tightly regulated for implantation in the human endometrium.

@article{Freyer2007ProproteinC,
  title={Pro-protein convertases (PCs) other than PC6 are not tightly regulated for implantation in the human endometrium.},
  author={Claudia Freyer and Lynette M Kilpatrick and Lois A. Salamonsen and Guiying Nie},
  journal={Reproduction},
  year={2007},
  volume={133 6},
  pages={1189-97}
}
Pro-protein convertases (PCs) are a family of serine proteases (furin, PC1/3, PC2, PACE4, PC4, PC5/6, PC7/8) responsible for post-translational processing and activation of inactive precursors of many regulatory proteins. Endometrial PC6 is critical for implantation in mice and for decidualization of human endometrial stromal cells (ESCs). This study investigated the endometrial expression of other PCs during the menstrual cycle and early pregnancy to elucidate potential redundancies. Furin… CONTINUE READING

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