Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension

@article{Savai2014ProproliferativeAI,
  title={Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension},
  author={Rajkumar Savai and Hamza M Al-Tamari and Daniel Sedding and Baktybek Kojonazarov and Christian Muecke and Rebecca Teske and Mario R Capecchi and Norbert Weissmann and Friedrich Grimminger and Werner Seeger and Ralph Theo Schermuly and Soni Savai Pullamsetti},
  journal={Nature Medicine},
  year={2014},
  volume={20},
  pages={1289-1300}
}
Pulmonary hypertension (PH) is characterized by increased proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs). Forkhead box O (FoxO) transcription factors are key regulators of cellular proliferation. Here we show that in pulmonary vessels and PASMCs of human and experimental PH lungs, FoxO1 expression is downregulated and FoxO1 is inactivated via phosphorylation and nuclear exclusion. These findings could be reproduced using ex vivo exposure of PASMCs to… CONTINUE READING
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