Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension

  title={Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension},
  author={Rajkumar Savai and Hamza M Al-Tamari and Daniel Sedding and Baktybek Kojonazarov and Christian Muecke and Rebecca Teske and Mario R Capecchi and Norbert Weissmann and Friedrich Grimminger and Werner Seeger and Ralph Theo Schermuly and Soni Savai Pullamsetti},
  journal={Nature Medicine},
Pulmonary hypertension (PH) is characterized by increased proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs). Forkhead box O (FoxO) transcription factors are key regulators of cellular proliferation. Here we show that in pulmonary vessels and PASMCs of human and experimental PH lungs, FoxO1 expression is downregulated and FoxO1 is inactivated via phosphorylation and nuclear exclusion. These findings could be reproduced using ex vivo exposure of PASMCs to… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 21 times over the past 90 days. VIEW TWEETS
35 Citations
68 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 35 extracted citations


Publications referenced by this paper.
Showing 1-10 of 68 references

Effects of multikinase inhibitors on pressure overload-induced right ventricular remodeling

  • B Kojonazarov
  • Int. J. Cardiol. 167,
  • 2013

The role of inflammation and autoimmunity in the pathophysiology of pulmonary arterial hypertension

  • N Kherbeck
  • Clin. Rev. Allergy Immunol
  • 2013

results of the randomized IMPRES study

  • Hoeper, M. M. et al. Imatinib mesylate as add-on therapy for hypertension
  • Circulation 127, 1128–1138
  • 2013

signalling integrators for homeostasis maintenance

  • A. Eijkelenboom, Burgering, B. M. FOXOs
  • Nat. Rev. Mol. Cell Biol. 14, 83–97
  • 2013

Similar Papers

Loading similar papers…