Pro-oxidative effect of beta-carotene and the interaction with flavonoids on UVA-induced DNA strand breaks in mouse fibroblast C3H10T1/2 cells.

@article{Yeh2005ProoxidativeEO,
  title={Pro-oxidative effect of beta-carotene and the interaction with flavonoids on UVA-induced DNA strand breaks in mouse fibroblast C3H10T1/2 cells.},
  author={Shu-Lan Yeh and Wei-Yu Wang and Chin-Hsiu Huang and Miao-lin Hu},
  journal={The Journal of nutritional biochemistry},
  year={2005},
  volume={16 12},
  pages={729-35}
}
It has been suggested that beta-carotene itself is unstable under certain conditions and that a combination of antioxidants may prevent the pro-oxidative effects of beta-carotene. Thus, the present study aimed to investigate the interaction of beta-carotene with three flavonoids-naringin, rutin and quercetin-on DNA damage induced by ultraviolet A (UVA) in C3H10T1/2 cells, a mouse embryo fibroblast. The cells were preincubated with beta-carotene and/or flavonoid for 1 h followed by UVA… CONTINUE READING

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