Pro-oxidants and mitochondrial Ca2+: their relationship to apoptosis and oncogenesis.

@article{Richter1993ProoxidantsAM,
  title={Pro-oxidants and mitochondrial Ca2+: their relationship to apoptosis and oncogenesis.},
  author={Christoph Richter},
  journal={FEBS letters},
  year={1993},
  volume={325 1-2},
  pages={104-7}
}
Apoptosis is a physiological process for active cell removal. One of its hallmarks is an increased cytosolic Ca2+ content. Several genes involved in apoptosis control have been identified, but their mode of action is not understood in detail. Apoptosis may relate to oncogenesis, in that some malignant tumors may grow because genes engaged in apoptosis control are altered. L929 cells overexpressing the proto-oncogene bcl-2 have an increased mitochondrial membrane potential (delta psi), as have… CONTINUE READING

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