Pro-oxidant action of diphenyl diselenide in the yeast Saccharomyces cerevisiae exposed to ROS-generating conditions.

@article{Rosa2005ProoxidantAO,
  title={Pro-oxidant action of diphenyl diselenide in the yeast Saccharomyces cerevisiae exposed to ROS-generating conditions.},
  author={Renato Moreira Rosa and Ramatis Birnfeld de Oliveira and Jenifer Saffi and Ant{\^o}nio Lu{\'i}s Braga and Rafael Roesler and Felipe Dal-Pizzol and Jos{\'e} Cl{\'a}udio Fonseca Moreira and Martin Brendel and Jo{\~a}o Antonio P{\^e}gas Henriques},
  journal={Life sciences},
  year={2005},
  volume={77 19},
  pages={
          2398-411
        }
}
Organoselenium compounds have a potential thiol peroxidase-like activity. Diphenyl diselenide (DPDS) is an electrophilic reagent used in the synthesis of a variety of pharmacologically active organic selenium compounds. Using TRAP assay of chemiluminescense we have shown that diphenyl diselenide clearly possesses a pro-oxidant property. For an investigation on the mechanisms of this property, we used mutant strains of Saccharomyces cerevisiae defective in antioxidant defenses, i.e. in… CONTINUE READING
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