Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity.

@article{Zhang2010ProopiomelanocortinGT,
  title={Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity.},
  author={Yi Edi Zhang and Enda Rodrigues and Yong Xin Gao and Michael King and K. Y. Cheng and Benedek Erd{\"o}s and Nihal T{\"u}mer and C Carter and Philip J. Scarpace},
  journal={Neuroscience},
  year={2010},
  volume={169 4},
  pages={1662-71}
}
Short-term pharmacological melanocortin activation deters diet-induced obesity (DIO) effectively in rodents. However, whether central pro-opiomelanocortin (POMC) gene transfer targeted to the hypothalamus or hindbrain nucleus of the solitary track (NTS) can combat chronic dietary obesity has not been investigated. Four-weeks-old Sprague-Dawley rats were fed a high fat diet for 5 months, and then injected with either the POMC or control vector into the hypothalamus or NTS, and body weight and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Role of oxytocin signaling in the regulation of body weight

Reviews in Endocrine and Metabolic Disorders • 2013
View 17 Excerpts
Highly Influenced

Neuroendocrine control of satiation.

Hormone molecular biology and clinical investigation • 2014
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Neuronal control of energy homeostasis

Q ao, TL Horvath
FEBS Lett 582:132–141 • 2008

Hypothalamic proopiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats

G i, Y Zhang, JT Wilsey, PJ Scarpace
Diabetologia • 2005

Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice

AC eijboer, AM van den Hoek, +4 authors EP Corssmit
Diabetologia • 2005

The impact of obesity on active life expectancy in older American men and women

SL eynolds, Y Saito, EM Crimmins
Gerontologist • 2005

Similar Papers

Loading similar papers…