Pro-opiomelanocortin-derived peptides induce IL-10 production in human monocytes.

  title={Pro-opiomelanocortin-derived peptides induce IL-10 production in human monocytes.},
  author={Rhanjit S. Bhardwaj and Agatha Schwarz and Eva Becher and Karsten Mahnke and Yoshinori Aragane and Thomas Schwarz and Thomas Anton Luger},
  journal={Journal of immunology},
  volume={156 7},
There is strong evidence for the existence of a neuroimmune axis which is regulated by a network of interacting cytokines and neuropeptides. Accordingly, pro-opiomelanocortin-derived peptide hormones such as melanocyte-stimulating hormones (MSH), adrenocorticotropin, and beta-endorphin not only could be detected in many immunocompetent cells but also turned… CONTINUE READING