Pro-opiomelanocortin and adrenal function.

  title={Pro-opiomelanocortin and adrenal function.},
  author={Andrew B. Bicknell and Demetris Savva and Philip J. Lowry},
  journal={Endocrine research},
  volume={22 4},
Pro-opiomelanocortin (POMC) is a polyhormone precursor produced predominantly in the pars distalis and pars intermedia of the pituitary gland where it undergoes tissue specific processing to produce a whole array of peptides. We have shown previously that peptides derived from the N-terminal region of POMC are involved in adrenal growth in rats. Using specific two site immunoradiometric assays we have found that the plasma of 17 week old fetal sheep contain a 50 fold excess of pro-gamma-MSH… CONTINUE READING

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