Pro-interleukin-1 beta production by a subpopulation of human T cells, but not NK cells, in response to interleukin-2.

@article{Numerof1990Prointerleukin1BP,
  title={Pro-interleukin-1 beta production by a subpopulation of human T cells, but not NK cells, in response to interleukin-2.},
  author={R P Numerof and A N Kotik and Charles A Dinarello and James Walter Mier},
  journal={Cellular immunology},
  year={1990},
  volume={130 1},
  pages={118-28}
}
Previous studies have shown that IL-2-stimulated peripheral blood mononuclear cells (PBMC) produce IL-1 beta and TNF alpha and that monocytes are the primary source of these IL-2-inducible cytokines. In this report, we provide evidence that monocytes are not the only source. We examined cytokine production by IL-2-treated, nonmonocytic PBMC and found that a population of nonadherent low-density cells (NLDC) produced both IL-1 beta and TNF alpha in response to IL-2. IL-1 beta was synthesized by… CONTINUE READING

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