Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.

@article{Saegusa2008ProinflammatorySP,
  title={Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.},
  author={Jun Saegusa and Nobuaki Akakura and Chun-Yi Wu and Case Hoogland and Zi Ma and Kit Sang Lam and F Liu and Yoko K. Takada and Yoshikazu Takada},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 38},
  pages={26107-15}
}
Secretory phospholipase A2 group IIA (sPLA2-IIA) plays an important role in the pathogenesis of inflammatory diseases. Catalytic activity of this enzyme that generates arachidonic acid is a major target for development of anti-inflammatory agents. Independent of its catalytic activity, sPLA2-IIA induces pro-inflammatory signals in a receptor-mediated mechanism (e.g. through the M-type receptor). However, the M-type receptor is species-specific: sPLA2-IIA binds to the M-type receptor in rodents… CONTINUE READING
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Integrins in sPLA2-IIA Signaling

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