Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid

Abstract

Immunoglobulin G (IgG) effector functions are regulated by the composition of glycans attached to a conserved N-glycosylation site in the Fc part. Intrathecal production of IgG, especially IgG1, is a hallmark of multiple sclerosis (MS), but nothing is known about IgG Fc glycosylation in MS and in cerebrospinal fluid (CSF) in general. We applied mass… (More)
DOI: 10.1186/s12974-015-0450-1

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@inproceedings{Wuhrer2015ProinflammatoryPO, title={Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid}, author={Manfred Wuhrer and Maurice H. J. Selman and Liam A McDonnell and Tania Kuempfel and Tobias J Derfuss and Mohsen Khademi and Tomas Olsson and Reinhard Hohlfeld and Edgar Meinl and Markus Krumbholz}, booktitle={Journal of Neuroinflammation}, year={2015} }