Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans.

@article{Fink2014ProinflammatoryMI,
  title={Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans.},
  author={Lisbeth Nielsen Fink and Sheila R. Costford and Yun Sok Lee and Thomas E Jensen and Philip J. Bilan and Andreas Oberbach and Matthias Bl{\"u}her and Jerrold M. Olefsky and Anette Sams and Amira Klip},
  journal={Obesity},
  year={2014},
  volume={22 3},
  pages={
          747-57
        }
}
OBJECTIVE In obesity, immune cells infiltrate adipose tissue. Skeletal muscle is the major tissue of insulin-dependent glucose disposal, and indices of muscle inflammation arise during obesity, but whether and which immune cells increase in muscle remain unclear. METHODS Immune cell presence in quadriceps muscle of wild type mice fed high-fat diet (HFD) was studied for 3 days to 10 weeks, in CCL2-KO mice fed HFD for 1 week, and in human muscle. Leukocyte presence was assessed by gene… CONTINUE READING
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