Pro-inflammatory cytokines: emerging players regulating HSC function in normal and diseased hematopoiesis.

  title={Pro-inflammatory cytokines: emerging players regulating HSC function in normal and diseased hematopoiesis.},
  author={Cristina Mirantes and Emmanuelle Passegu{\'e} and Eric M. Pietras},
  journal={Experimental cell research},
  volume={329 2},
Hematopoiesis is the hierarchical process in which all lineages of blood cells are produced by self-renewing hematopoietic stem cells (HSCs) in the bone marrow (BM). While the regulatory factors that maintain proper HSC function and lineage output under normal conditions are well understood, significantly less is known about how HSC fate is regulated in response to inflammation or disease. As many blood disorders are associated with overproduction of pro-inflammatory cytokines, significant… CONTINUE READING
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