Pro-erectile effect of vardenafil: in vitro experiments in rabbits and in vivo comparison with sildenafil in rats.

@article{Giuliano2003ProerectileEO,
  title={Pro-erectile effect of vardenafil: in vitro experiments in rabbits and in vivo comparison with sildenafil in rats.},
  author={François Alexandre Giuliano and J. J. Morell Bernab{\'e} and L. Nascentes Alexandre and Ulrich Dr. Niew{\"o}hner and H. M. Thahir Haning and Ernst Philipp Eduard Bischoff},
  journal={European urology},
  year={2003},
  volume={44 6},
  pages={
          731-6
        }
}
OBJECTIVES To assess pro-erectile responses to vardenafil, a new selective PDE5 inhibitor, in vitro in isolated rabbit corpora cavernosa, and in vivo in anaesthetized rats. METHODS Rabbit cavernosal strips were precontracted with 10 microM phenylephrine. Dose-response relaxation curves to cumulative dosings of vardenafil (1 nM-10 microM) were constructed alone and in the presence of 10 mM L-NAME. Relaxation responses to electrical field stimulation (EFS) (2 Hz, 2 ms, 10 V) were compared in… CONTINUE READING
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