Pro-coagulant state resulting from high levels of soluble P-selectin in blood.

  title={Pro-coagulant state resulting from high levels of soluble P-selectin in blood.},
  author={Patrick Andr{\'e} and Dorthe Hartwell and Ingrid Hrachovinov{\'a} and Simin Saffaripour and Denisa D Wagner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 25},
The plasma concentration of soluble adhesion receptors is increased under pathological circumstances, but their function remains enigmatic. Soluble P-selectin (sP-sel) is shed from activated platelets and endothelial cells. Mice genetically engineered to express P-selectin without the cytoplasmic tail (DeltaCT) constitutively show a 3- to 4-fold increase of sP-sel in plasma. We observed that the DeltaCT mice formed fibrin very readily. In an ex vivo perfusion chamber, there was more fibrin… CONTINUE READING


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