Pro-apoptotic signaling pathway activated by echistatin in GD25 cells.

  title={Pro-apoptotic signaling pathway activated by echistatin in GD25 cells.},
  author={Elena Alimenti and Simona Tafuri and Antonio Scibelli and Danila d'Angelo and Laura Manna and Luigi Michele Pavone and Maria Antonietta Belisario and Norma Staiano},
  journal={Biochimica et biophysica acta},
  volume={1693 1},
Disintegrins, low molecular weight RGD-containing polypeptides isolated from snake venoms, have seen use as integrin antagonists in the field of tumor biology and angiogenesis. In this study, we investigated the molecular mechanism by which the disintegrin echistatin affects cell adhesion and signaling resulting in an apoptotic response in the GD25 cell system. Wild-type GD25 cells, which lack expression of the beta(1) family of integrin, and stable transfectants expressing the A isoform of… CONTINUE READING