Pro-apoptotic effects of imatinib on PDGF-stimulated pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension.

@article{Nakamura2012ProapoptoticEO,
  title={Pro-apoptotic effects of imatinib on PDGF-stimulated pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension.},
  author={Kazufumi Nakamura and Satoshi Akagi and Aiko Ogawa and Kengo Kusano and Hiromi Matsubara and Daiji Miura and Soichiro Fuke and Nobuhiro Nishii and Satoshi Nagase and Kunihisa Kohno and Hiroshi Morita and Takahiro Oto and Ryutaro Yamanaka and Fumio Otsuka and Aya Miura and Chikao Yutani and Tohru Ohe and Hiroshi Ito},
  journal={International journal of cardiology},
  year={2012},
  volume={159 2},
  pages={100-6}
}
BACKGROUND Remodeling of the pulmonary artery by an inappropriate increase of pulmonary artery smooth muscle cells (PASMCs) is problematic in the treatment of idiopathic pulmonary arterial hypertension (IPAH). Effective treatment that achieves reverse remodeling is required. The aim of this study was to assess the pro-apoptotic effects of imatinib, a platelet-derived growth factor (PDGF)-receptor tyrosine kinase inhibitor, on PASMCs obtained from patients with IPAH. METHODS PASMCs were… CONTINUE READING

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