Pro-apoptotic effect of endogenous H2S on human aorta smooth muscle cells.

  title={Pro-apoptotic effect of endogenous H2S on human aorta smooth muscle cells.},
  author={Guangdong Yang and Ling-Yun Wu and Rui Wang},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={20 3},
Cystathionine gamma-lyase (CSE) is a key enzyme in the trans-sulfuration pathway, which uses L-cysteine to produce hydrogen sulfide (H2S). The CSE/H2S system has been shown to play an important role in regulating cellular functions in different systems. In the present study, we overexpressed CSE in human aorta smooth muscle cells (HASMCs) using a recombinant defective adenovirus containing CSE gene (Ad-CSE). Infection of HASMCs with Ad-CSE resulted in a significant increase in the expression of… CONTINUE READING
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