Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins

@article{Torii2011ProapoptoticAO,
  title={Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins},
  author={Seiji Torii and Yusuke Goto and Toshiyuki Ishizawa and Hisae Hoshi and Kenji Goryo and Ken-ichi Yasumoto and Hidenobu Fukumura and Kazuhiro Sogawa},
  journal={Cell Death and Differentiation},
  year={2011},
  volume={18},
  pages={1711-1725}
}
Inhibitory PAS (Per/Arnt/Sim) domain protein (IPAS) is a dominant negative transcription factor that represses hypoxia-inducible factor 1 (HIF-1) activity. In this study, we show that IPAS also functions as a pro-apoptotic protein through binding to pro-survival Bcl-2 family members. In a previous paper, we reported that NF-κB-dependent IPAS induction by cobalt chloride repressed the hypoxic response in PC12 cells. We found that prolonged incubation under the same conditions caused apoptosis in… CONTINUE READING

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