Pro-apoptotic Sorafenib signaling in murine hepatocytes depends on malignancy and is associated with PUMA expression in vitro and in vivo

@inproceedings{Sonntag2014ProapoptoticSS,
  title={Pro-apoptotic Sorafenib signaling in murine hepatocytes depends on malignancy and is associated with PUMA expression in vitro and in vivo},
  author={Roland Sonntag and Nikolaus Gassler and J-M Bangen and Christian Trautwein and Christian Liedtke},
  booktitle={Cell Death and Disease},
  year={2014}
}
The multi-kinase inhibitor Sorafenib increases the survival of patients with advanced hepatocellular carcinoma (HCC). Current data suggest that Sorafenib inhibits cellular proliferation and angiogenesis and promotes apoptosis. However, the underlying pro-apoptotic molecular mechanisms are incompletely understood. Here we compared the pro-apoptotic and anti… CONTINUE READING