Pro-apoptotic Bim induction in response to nerve growth factor deprivation requires simultaneous activation of three different death signaling pathways.

@article{Biswas2007ProapoptoticBI,
  title={Pro-apoptotic Bim induction in response to nerve growth factor deprivation requires simultaneous activation of three different death signaling pathways.},
  author={Subhas Chandra Biswas and Yijie Shi and Andrew A. Sproul and Lloyd A Greene},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 40},
  pages={
          29368-74
        }
}
Bim is a pro-apoptotic member of the Bcl-2 family that is induced and contributes to neuron death in response to nerve growth factor (NGF) deprivation. Past work has revealed that Bim is downstream of multiple independent transcriptional pathways in neurons, including those culminating in activation of the c-Jun, FoxO, and Myb transcription factors. This study addresses the issue of whether the three signaling pathways are redundant with respect to Bim induction or whether they act… CONTINUE READING
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