Pro-angiogenic signaling by the endothelial presence of CEACAM1.

  title={Pro-angiogenic signaling by the endothelial presence of CEACAM1.},
  author={N. Koray Kilic and Leticia Oliveira-Ferrer and Jan-Henner Wurmbach and Sonja Loges and Fariba Chalajour and Samira Neshat-Vahid and Joachim Weil and Malkanthi Fernando and Suleyman Ergun},
  journal={The Journal of biological chemistry},
  volume={280 3},
Here, we demonstrate the expression of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) in angiogenic sprouts but not in large mother blood vessels within tumor tissue. Correspondingly, only human microvascular endothelial cells involved in in vitro tube formation exhibit CEACAM1. CEACAM1-overexpressing versus CEACAM1-silenced human microvascular endothelial cells were used in migration and tube formation assays. CEACAM1-overexpressing microvascular endothelial cells showed… CONTINUE READING
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