Pro- and anticonvulsant effects of anesthetics (Part I)

  title={Pro- and anticonvulsant effects of anesthetics (Part I)},
  author={P A Modica and Ren{\'e} Tempelhoff and Paul F. White},
  journal={Anesthesia and analgesia},
  volume={70 3},
Many inhaled anesthetics and intravenous analgesics have been alleged to produce both proconvulsant and anticonvulsant activity in humans. The reasons for these contrasting actions on the CNS are poorly understood at the present time. However, biologic variability plays an important role in determining individual patient's responses to anesthetic and analgesic drugs. In addition, variations in the responsiveness of inhibitory and excitatory neurons to the central depressant effects of these… CONTINUE READING