Pro- and anticoagulant properties of factor V in pathogenesis of thrombosis and bleeding disorders.

@article{Dahlbck2016ProAA,
  title={Pro- and anticoagulant properties of factor V in pathogenesis of thrombosis and bleeding disorders.},
  author={Bj{\"o}rn Dahlb{\"a}ck},
  journal={International journal of laboratory hematology},
  year={2016},
  volume={38 Suppl 1},
  pages={4-11}
}
Factor V (FV) serves an important role in the regulation of blood coagulation, having both pro- and anticoagulant properties. The circulating high molecular weight single-chain FV molecule undergoes a series of proteolytic cleavages during both activation of coagulation and during anticoagulant regulation of coagulation by activated protein C (APC). It is noteworthy that mutations in the factor V gene (F5) either cause thrombosis or bleeding. New insights into the importance and complexity of… CONTINUE READING