Pro- and anti-inflammatory factors cooperate to control hyaluronan synthesis in lung fibroblasts.

@article{Wilkinson2004ProAA,
  title={Pro- and anti-inflammatory factors cooperate to control hyaluronan synthesis in lung fibroblasts.},
  author={Thomas S. Wilkinson and Susan Potter-Perigo and Christina Tsoi and Leonard C. Altman and Thomas N Wight},
  journal={American journal of respiratory cell and molecular biology},
  year={2004},
  volume={31 1},
  pages={92-9}
}
Hyaluronan (HA) is an important constituent of the extracellular matrix and accumulates during inflammatory lung diseases like asthma. Little is known about the factors that regulate HA synthesis by lung cells. Accordingly, we investigated the effect of T-helper 1 (TH1) and 2 (TH2) cytokines and the anti-inflammatory agents fluticasone and salmeterol on HA synthesis in human lung fibroblasts. Interleukin-1beta (IL-1beta) and tumor necrosis factor (TNF)-alpha were the most potent stimulators of… CONTINUE READING

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