Pro- and anti-inflammatory cytokines in tuberculosis: a two-edged sword in TB pathogenesis.

@article{Etna2014ProAA,
  title={Pro- and anti-inflammatory cytokines in tuberculosis: a two-edged sword in TB pathogenesis.},
  author={Marilena P Etna and Elena Giacomini and Martina Severa and Eliana M Coccia},
  journal={Seminars in immunology},
  year={2014},
  volume={26 6},
  pages={543-51}
}
A major challenge in tuberculosis (TB) is to improve current vaccination and therapeutic strategies and this requires a fine understanding of the mechanisms that mediate protection and pathogenesis. We need to discern how the host perceives Mycobacterium tuberculosis (Mtb) infection, what are the danger signals that activate the immune system and, in turn, how the immune response controls the life-cycle of Mtb. Cytokines, because of their nature of soluble mediators, represent key elements in… CONTINUE READING