Pro-Inflammatory and Pro-Oxidant Status of Pancreatic Islet In Vitro Is Controlled by TLR-4 and HO-1 Pathways

@inproceedings{Vivot2014ProInflammatoryAP,
  title={Pro-Inflammatory and Pro-Oxidant Status of Pancreatic Islet In Vitro Is Controlled by TLR-4 and HO-1 Pathways},
  author={Kevin Vivot and Allan Langlois and William Bietiger and St{\'e}phanie Dal and Elodie Seyfritz and Michel Pinget and Nathalie Jeandidier and E Maillard and Jean-Pierre Gies and S{\'e}verine Sigrist and Patr{\'i}cia Torres Bozza},
  booktitle={PloS one},
  year={2014}
}
Since their isolation until implantation, pancreatic islets suffer a major stress leading to the activation of inflammatory reactions. The maintenance of controlled inflammation is essential to preserve survival and function of the graft. Identification and targeting of pathway(s) implicated in post-transplant detrimental inflammatory events, is mandatory to improve islet transplantation success. We sought to characterize the expression of the pro-inflammatory and pro-oxidant mediators during… CONTINUE READING
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