Pro-Aging Effects of Glucose Signaling through a G Protein-Coupled Glucose Receptor in Fission Yeast

@article{Roux2009ProAgingEO,
  title={Pro-Aging Effects of Glucose Signaling through a G Protein-Coupled Glucose Receptor in Fission Yeast},
  author={Antoine E. Roux and Alexandre Leroux and Manal A. Alaamery and Charles S Hoffman and Pascal Chartrand and Gerardo Ferbeyre and Luis A. Rokeach},
  journal={PLoS Genetics},
  year={2009},
  volume={5},
  pages={787 - 790}
}
Glucose is the preferred carbon and energy source in prokaryotes, unicellular eukaryotes, and metazoans. However, excess of glucose has been associated with several diseases, including diabetes and the less understood process of aging. On the contrary, limiting glucose (i.e., calorie restriction) slows aging and age-related diseases in most species. Understanding the mechanism by which glucose limits life span is therefore important for any attempt to control aging and age-related diseases… CONTINUE READING

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