Privileged scaffolds for library design and drug discovery.


This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives: to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present state of the art in privileged scaffold library synthesis (in hopes of inspiring new and even more creative approaches); and also to offer some thoughts on how new privileged scaffolds might be identified and exploited.

DOI: 10.1016/j.cbpa.2010.02.018

Extracted Key Phrases

5 Figures and Tables

Citations per Year

257 Citations

Semantic Scholar estimates that this publication has 257 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Welsch2010PrivilegedSF, title={Privileged scaffolds for library design and drug discovery.}, author={Matthew E. Welsch and Scott A. Snyder and Brent R. Stockwell}, journal={Current opinion in chemical biology}, year={2010}, volume={14 3}, pages={347-61} }