Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway.

@article{Lai2007PrivilegedDO,
  title={Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway.},
  author={Samuel K Lai and Kaoru Hida and Stan T Man and Clive Chen and Carolyn E. Machamer and Trina A Schroer and Justin Hanes},
  journal={Biomaterials},
  year={2007},
  volume={28 18},
  pages={2876-84}
}
The efficacy of many therapeutic molecules could be greatly enhanced by polymer-based nanoparticle systems capable of delivering them to the direct vicinity of the cell nucleus. However, degradation of the particles and encapsulated drugs within the enzyme-rich and low-pH environments of the endo/lysosomal pathway of cells has dramatically limited the efficacy of such systems. In this paper, we discovered that small polymeric particles (<25 nm) but not larger particles (>42 nm) enter live cells… CONTINUE READING

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