Privileged access to mitochondria of calcium influx through N-methyl-D-aspartate receptors.

@article{Peng1998PrivilegedAT,
  title={Privileged access to mitochondria of calcium influx through N-methyl-D-aspartate receptors.},
  author={Tao Peng and J Timothy Greenamyre},
  journal={Molecular pharmacology},
  year={1998},
  volume={53 6},
  pages={974-80}
}
Mitochondrial Ca2+ uptake responds dynamically and sensitively to changes in cytosolic Ca2+ levels and plays a crucial role in sequestering the large Ca2+ load induced by N-methyl-D-aspartate (NMDA) receptor activation. However, the precise interrelationships between NMDA receptor activation, cytosolic Ca2+ increase, and mitochondrial Ca2+ uptake remain obscure. To reliably, independently, and simultaneously detect cytosolic and mitochondrial Ca2+ concentration changes in the same cell, we… CONTINUE READING
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