Pristane primed rat T cells enhance TLR3 expression of fibroblast-like synoviocytes via TNF-α initiated p38 MAPK and NF-κB pathways.

@article{Zhu2015PristanePR,
  title={Pristane primed rat T cells enhance TLR3 expression of fibroblast-like synoviocytes via TNF-α initiated p38 MAPK and NF-κB pathways.},
  author={Wenhua Zhu and Congshan Jiang and Jing Li Xu and Manman Geng and Xiaoying Wu and Jian Sun and Jie Ma and Rikard Holmdahl and Liesu Meng and Shemin Lu},
  journal={Clinical immunology},
  year={2015},
  volume={156 2},
  pages={141-53}
}
Based on pristane-induced arthritis (PIA), we found that T cells mediate TLR3 overexpression in fibroblast-like synoviocytes (FLS). The aim of this study is to determine key factors by which T cells induce TLR3 expression. Rat FLS were co-cultured with pristane primed T cell conditioned medium (PPT medium), and TLR3 expression of FLS was significantly induced. TNF-α, IFN-γ and IL-17 were dominantly expressed in PIA T cells. The overexpression of TLR3 and its related genes in FLS co-cultured… CONTINUE READING