Intracellular viral interaction is a system which is commonly modeled in evolutionary game theory. Current theoretical approaches are applying either the prisoner’s dilemma or snowdrift games to model viral interactions (Doebeli, 2005). The problem with this approach is that it ignores the biological mechanisms which lead to the outcomes, thereby leading to conclusions of limited significance. Subsequently the strategies profiles are not linked to the biological processes. Through consideration of the biological mechanisms and subsequent assignment of it into a group, of either cooperating or defecting actions, a game matrix can be constructed which will provide a more realistic model for the viral interactions. This construct can further be analyzed to determine if the viruses that follow a prisoner’s dilemma model or snowdrift model game are evolutionary superior.