Prior test experience compromises the anxiolytic efficacy of chlordiazepoxide in the mouse light/dark exploration test.

@article{Holmes2001PriorTE,
  title={Prior test experience compromises the anxiolytic efficacy of chlordiazepoxide in the mouse light/dark exploration test.},
  author={Andrew M Holmes and Jon P. Iles and Sarah J Mayell and Robert John Rodgers},
  journal={Behavioural brain research},
  year={2001},
  volume={122 2},
  pages={159-67}
}
It is now well established that prior test experience can alter behavioural baselines and attenuate/abolish the anxiolytic efficacy of benzodiazepines in the elevated plus-maze paradigm. In view of evidence that different models of anxiety measure qualitatively distinct forms of anxiety-like behaviour, it is important to establish whether the effects of prior experience extend to other widely-used tests. The present study assessed the behavioural and pharmacological sequelae of a single… CONTINUE READING
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Relationship of negative contrast to animal models of fear and anxiety

  • CF Flaherty, A Greenwood, J Martin, M. Leszczuk
  • Anim Learn Behav 1998;26:397–407
  • 1998

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