Prior regular exercise improves clinical outcome and reduces demyelination and axonal injury in experimental autoimmune encephalomyelitis.

@article{Bernardes2016PriorRE,
  title={Prior regular exercise improves clinical outcome and reduces demyelination and axonal injury in experimental autoimmune encephalomyelitis.},
  author={Danielle Bernardes and Roberta Brambilla and Valerie C. Bracchi-Ricard and Shaffiat A. Karmally and Anna Dellarole and Juliana Carvalho-Tavares and John R. Bethea},
  journal={Journal of neurochemistry},
  year={2016},
  volume={136 Suppl 1},
  pages={63-73}
}
Although previous studies have shown that forced exercise modulates inflammation and is therapeutic acutely for experimental autoimmune encephalomyelitis (EAE), the long-term benefits have not been evaluated. In this study, we investigated the effects of preconditioning exercise on the clinical and pathological progression of EAE. Female C57BL/6 mice were randomly assigned to either an exercised (Ex) or unexercised (UEx) group and all of them were induced for EAE. Mice in the Ex group had an… CONTINUE READING
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