Prior genital tract infection with a murine or human biovar of Chlamydia trachomatis protects mice against heterotypic challenge infection.

@article{Ramsey1999PriorGT,
  title={Prior genital tract infection with a murine or human biovar of Chlamydia trachomatis protects mice against heterotypic challenge infection.},
  author={Kyle H. Ramsey and T W Cotter and Rena D Salyer and Gurwattan S. Miranpuri and Marco A. Y{\'a}{\~n}ez and C E Poulsen and Jennifer L Dewolfe and Gerald I. Byrne},
  journal={Infection and immunity},
  year={1999},
  volume={67 6},
  pages={3019-25}
}
We sought to assess the degree of cross-protective immunity in a mouse model of chlamydial genital tract infection. Following resolution of genital infection with the mouse pneumonitis (MoPn) biovar of Chlamydia trachomatis, mice were challenged intravaginally with either MoPn or human serovar E or L2. The majority of animals previously infected with MoPn were solidly immune to challenge with either of the two human biovars. Surprisingly, approximately 50% of animals became reinfected when… CONTINUE READING

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