• Corpus ID: 5888930

Prior experience, antioxidants, and mitochondrial cofactors improve cognitive function in aged beagles.

@article{IkedaDouglas2004PriorEA,
  title={Prior experience, antioxidants, and mitochondrial cofactors improve cognitive function in aged beagles.},
  author={Candace J. Ikeda-Douglas and Steven Curtis Zicker and Jimena Estrada and Dennis E. Jewell and Norton William Milgram},
  journal={Veterinary therapeutics : research in applied veterinary medicine},
  year={2004},
  volume={5 1},
  pages={
          5-16
        },
  url={https://api.semanticscholar.org/CorpusID:5888930}
}
Results of this study support the free-radical theory of aging and demonstrated that providing higher levels of vitamin E in food resulted in higher serum vitamin E concentrations and improved…
View on PubMed
31 Citations
Background Citations
13

Figures and Tables from this paper

31 Citations

Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine.

It is suggested that the nutraceutical supplement can improve memory in aged dogs and the effect was long lasting.

Short-term supplementation with acetyl-l-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles

Nutraceuticals for Cognitive Dysfunction

Various nutraceuticals and substances that have potential to improve cognition and memory in senior dogs and cats are described.

Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification : a two-year longitudinal study

It is suggested that behavioral enrichment or dietary fortification with antioxidants over a long-duration can slow age-dependent cognitive decline, and that the two treatments together are more effective than either alone in older dogs.

Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study

Integrative Nutritional Therapy in Canine Cognitive Dysfunction

Conventional dietary intervention in dogs, along with traditional Chinese food therapy according to pattern diagnosis in CCD, and a combination of syndrome differentiation in CFT and conventional nutritional therapy may help improve cognition and quality of life in patients with CCD are discussed.

Therapeutic agents for the treatment of cognitive dysfunction syndrome in senior dogs

Nutrition and behavior in senior dogs.

Dietary treatment of CDS has been based on the use of antioxidants and mitochondrial cofactors, and recent work has shown that long-term supplementation with medium-chain triglycerides can improve cognitive function in aged dogs.

The effects of long-term honey, sucrose or sugar-free diets on memory and anxiety in rats

Therapeutic options for cognitive decline in senior pets.

The theory, evidence of efficacy, and potential neuroprotective effects of products used to treat cognitive dysfunction, including drugs, nutritional supplements, and diets for senior pets are described.

51 References

Dietary enrichment counteracts age-associated cognitive dysfunction in canines

Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats

Vitamin E and cognitive decline in older persons.

Vitamin E intake, from foods or supplements, is associated with less cognitive decline with age, and there was little evidence of association with vitamin C or carotene intake.

Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction

Chronic antioxidant treatment improves the cognitive performance of aged rats

Long-Term Dietary Strawberry, Spinach, or Vitamin E Supplementation Retards the Onset of Age-Related Neuronal Signal-Transduction and Cognitive Behavioral Deficits

Phytochemicals present in antioxidant-rich foods such as spinach may be beneficial in retarding functional age-related CNS and cognitive behavioral deficits and, perhaps, may have some benefit in neurodegenerative disease.

Vitamin E and other antioxidants in neuroprotection.

    C. Behl
    Chemistry, Medicine
    International journal for vitamin and nutrition…
  • 1999
Optimistic data concerning the neuroprotective activity of antioxidants in vitro and in vivo underline an important role for antioxidative acting compounds for the prevention and therapy of oxidative stress-related conditions including AD.

Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation

Findings suggest that, in addition to their known beneficial effects on cancer and heart disease, phytochemicals present in antioxidant-rich foods may be beneficial in reversing the course of neuronal and behavioral aging.

Aging‐ and Oxygen‐induced Modifications in Brain Biochemistry and Behavior a

The hypothesis that inability to restrain age- or pathology-related increases in local ROS activity can result in AD is supported, as well as the distribution of index enzyme inactivation and the known intensity distribution of AD pathology.

Oxidative damage increases with age in a canine model of human brain aging

Evidence of widespread oxidative damage and Aβ deposition is further justification for using the canine model for studying human brain aging and neurodegenerative diseases.
...