Prior event rate ratio adjustment: numerical studies of a statistical method to address unrecognized confounding in observational studies.

@article{Yu2012PriorER,
  title={Prior event rate ratio adjustment: numerical studies of a statistical method to address unrecognized confounding in observational studies.},
  author={Menggang Yu and Dawei Xie and Xingmei Wang and Mark G. Weiner and Richard L Tannen},
  journal={Pharmacoepidemiology and drug safety},
  year={2012},
  volume={21 Suppl 2},
  pages={60-8}
}
PURPOSE The purpose of this study was to evaluate a statistical method, prior event rate ratio (PERR) adjustment, and an alternative, PERR-ALT, both of which have the potential to overcome "unmeasured confounding," both analytically and via simulation. METHODS Formulae were derived for the target estimates of both PERR methods, which were compared with results from simulations to ensure their validity. In addition to the theoretical insights gained, relative biases of both PERR methods for… CONTINUE READING