Prior cocaine exposure disrupts extinction of fear conditioning.

  title={Prior cocaine exposure disrupts extinction of fear conditioning.},
  author={Kathryn A. Burke and Theresa M. Franz and Nishan Gugsa and Geoffrey Schoenbaum},
  journal={Learning & memory},
  volume={13 4},
Psychostimulant exposure has been shown to cause molecular and cellular changes in prefrontal cortex. It has been hypothesized that these drug-induced changes might affect the operation of prefrontal-limbic circuits, disrupting their normal role in controlling behavior and thereby leading to compulsive drug-seeking. To test this hypothesis, we tested cocaine-treated rats in a fear conditioning, inflation, and extinction task, known to depend on medial prefrontal cortex and amygdala. Cocaine… CONTINUE READING