Prions on the move.

  title={Prions on the move.},
  author={Charles Weissmann and Jiali Li and Sukhvir Paul Mahal and Shawn R Browning},
  journal={EMBO reports},
  volume={12 11},
Prions consist mainly, if not entirely, of PrP(Sc), an aggregated conformer of the host protein PrP(C). Prions come in different strains, all based on the same PrP(C) sequence, but differing in their conformations. The efficiency of prion transmission between species is usually low, but increases after serial transmission in the new host, suggesting a process involving mutation and selection. Even within the same species, the transfer of prions between cell types entails a selection of favoured… CONTINUE READING
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