Prions in Saccharomyces and Podospora spp.: protein-based inheritance.

  title={Prions in Saccharomyces and Podospora spp.: protein-based inheritance.},
  author={Reed B Wickner and Kimberly L. Taylor and Herman K. Edskes and M. L. Maddelein and Hiromitsu Moriyama and Bruce T Roberts},
  journal={Microbiology and molecular biology reviews : MMBR},
  volume={63 4},
  pages={844-61, table of contents}
Genetic evidence showed two non-Mendelian genetic elements of Saccharomyces cerevisiae, called [URE3] and [PSI], to be prions of Ure2p and Sup35p, respectively. [URE3] makes cells derepressed for nitrogen catabolism, while [PSI] elevates the efficiency of weak suppressor tRNAs. The same approach led to identification of the non-Mendelian element [Het-s] of… CONTINUE READING